She started her American professional career playing for the Columbus Quest in the now-defunct American Basketball League (ABL). After the ABL ceased operations, she joined the Women's National Basketball Association and played for the Minnesota Lynx for three seasons.
After her playing career she served three years as an assistant coach for the women's basketball team at Ohio University. In August 2006, she was named as an assistant coach at University of San Francisco. Stires is also currently pursuing a Master's Degree in Coaching Education from Ohio University.
Her brother, Sean Stires, is a play-by-play radio announcer for the Notre Dame University's baseball team and women's basketball team .